The church father Ignatius of Antioch was its third bishop.The School of Antioch, founded in 270, was one of two major centers of early church learning.When Bar Cochba was defeated, Hadrian barred Jews from the city, except for the day of Tisha B'Av, thus the subsequent Jerusalem bishops were gentiles ("uncircumcised") for the first time.

The Council of Nicaea in canon VI affirmed Alexandria's traditional authority over Egypt, Libya, and Pentapolis (North Africa) (the Diocese of Egypt) and probably granted Alexandria the right to declare a universal date for the observance of Easter, The tradition of John the Apostle was strong in Anatolia (the near-east, part of modern Turkey, the western part was called the Roman province of Asia).

The authorship of the Johannine works traditionally and plausibly occurred in Ephesus, c.

The first followers of Christianity were Jews or proselytes, commonly referred to as Jewish Christians and God-fearers.

The Apostolic sees claim to have been founded by one or more of the apostles of Jesus, who are said to have dispersed from Jerusalem sometime after the crucifixion of Jesus, c. Early Christians gathered in small private homes, but is translated as church in most English translations of the New Testament.

Pliny, governor in 110, in his letters, addressed Christians in Pontus.

Of the extant letters of Ignatius of Antioch considered authentic, five of seven are to Anatolian cities, the sixth is to Polycarp.

The Book of Revelation, believed to be authored by John of Patmos (a Greek island about 30 miles off the Anatolian coast), mentions Seven churches of Asia.

The First Epistle of Peter (1:1–2) is addressed to Anatolian regions.

Early Christianity (generally considered the time period from its start to 325), spread from the Eastern Mediterranean throughout the Roman Empire and beyond.